Liverpool will continue the defence of their Champions League crown with a two-legged tie against Atletico Madrid in the last 16, whom they last faced in a European knockout game in 2009/2010 which Atletico Madrid prevailed on away goals.
While Manchester City take on Real Madrid in their toughest knockout game yet under the tutelage of Pep Guardiola.
Chelsea will be involved in another heavyweight tie, as they face German giants Bayern Munich whom they vanquished in the final of the 2012 Champions League.
Tottenham the beaten finalists from 2019 must try and overcome a youthful Julian Nagelsmann’s RB Leipzig who currently top the Bundesliga.
Barcelona will try to eliminate Napoli as they try to win the Champions League trophy which has eluded them since 2015. But they must hope Messi is at his talismanic best to have any chance of pulling that.
Paris Saint-Germain, who have flattered to deceive in recent years have another chance to challenge with Neymar and Kylian Mbappe leading the charge, will take in a tough test against Borussia Dortmund.
Cristiano Ronaldo, who is the competition’s all-time leading goalscorer, can add to his stunning collection of continental efforts in a meeting with Lyon who lost Memphis Depay and Jeff Reine-Adelaide to injuries.
While this season’s surprise package, Atalanta who are gracing this stage for the first time will fancy their chances against Valencia.